Title : Fc-receptor-mediated intracellular delivery of Cu/Zn-superoxide dismutase (SOD1) protects against redox-induced apoptosis through a nitric oxide dependent mechanism.

Pub. Date : 2000 Dec

PMID : 11474120






3 Functional Relationships(s)
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1 The Fc-mediated intracellular delivery of SOD1 thus limited the endogenous production of superoxide. Superoxides superoxide dismutase 1, soluble Mus musculus
2 The concomitant stimulation of the FcyR and the translocation of the SOD1 in the cytoplasm of IFN-gamma-activated macrophages not only reduced the production of superoxide anion but also induced the expression of the inducible form of nitric oxide synthase (iNOS) and the related NO production. Superoxides superoxide dismutase 1, soluble Mus musculus
3 In this work, we propose that Fc-mediated intracellular delivery of the SOD1 that reduced the production of superoxide anion and of peroxynitrite, promoted a NO-induced protective effect in inducing the antioxidant armature of the cells. Superoxides superoxide dismutase 1, soluble Mus musculus