Pub. Date : 2001 Jul
PMID : 11465558
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The current study aimed to examine whether induction of HO-1 and its by-products modulated endothelial interaction with circulating leukocytes and platelets evoked by sevoflurane anesthesia in vivo. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 2 | Pretreatment with hemin, a HO-1 inducer, prevented such sevoflurane-elicited changes in the microvessels. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 3 | CONCLUSIONS: These results indicate that endogenous CO via HO-1 induction attenuates sevoflurane-induced microvascular endothelial interactions with leukocytes and platelets, although local nitric oxide levels appear to dominate microvascular flow in situ. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |