Pub. Date : 2001 Jul
PMID : 11441127
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. | Triglycerides | stearoyl-Coenzyme A desaturase 1 | Mus musculus |
| 2 | Stearoyl-CoA desaturase (SCD) catalyzes the de novo biosynthesis of oleate and palmitoleate, which are the major fatty acids found in triglycerides, cholesteryl esters, and phospholipids. | Triglycerides | stearoyl-Coenzyme A desaturase 1 | Mus musculus |
| 3 | Triglyceride synthesis, as measured by the incorporation of [(3)H]glycerol, was dramatically reduced in the liver of SCD-/- mouse fed a lipogenic diet compared with the normal mouse. | Triglycerides | stearoyl-Coenzyme A desaturase 1 | Mus musculus |
| 4 | These observations demonstrate that induction of triglyceride synthesis is highly dependent on SCD1 gene expression. | Triglycerides | stearoyl-Coenzyme A desaturase 1 | Mus musculus |