Title : Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure.

Pub. Date : 2001 Jun

PMID : 11428664






2 Functional Relationships(s)
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1 In Caco-2 cells, plasma collected from CCl4-treated rats exhibited a greater inhibitory effect on P-glycoprotein-mediated transport of rhodamine 123 than that from control rats, suggesting the accumulation of an endogenous P-glycoprotein substrate/inhibitor in the plasma of diseased rats. Rhodamines ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 In Caco-2 cells, plasma collected from CCl4-treated rats exhibited a greater inhibitory effect on P-glycoprotein-mediated transport of rhodamine 123 than that from control rats, suggesting the accumulation of an endogenous P-glycoprotein substrate/inhibitor in the plasma of diseased rats. Rhodamines ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus