Pub. Date : 2001
PMID : 11401329
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. | Tyrosine | catenin beta 1 | Homo sapiens |
| 2 | Tyrosine phosphorylation of beta-catenin has been shown to correlate with tumorigenesis, cell migration, and developmental processes. | Tyrosine | catenin beta 1 | Homo sapiens |
| 3 | Treatment with a PTPase inhibitor, pervanadate, increased the tyrosine phosphorylation of beta-catenin in a time-dependent manner and led to its relocation from cell-cell interfaces to the cytoplasm. | Tyrosine | catenin beta 1 | Homo sapiens |
| 4 | However, tyrosine phosphorylation of beta-catenin does not change its binding affinity to LEF-1 nor enhance cyclin D1 transactivation, a nuclear target of beta-catenin/LEF-1. | Tyrosine | catenin beta 1 | Homo sapiens |
| 5 | This result suggests that tyrosine phosphorylation of beta-catenin has effects on the binding to cadherins in the cytoplasm but not on its LEF-1-dependent transactivating function in the nucleus. | Tyrosine | catenin beta 1 | Homo sapiens |