Title : The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages.

Pub. Date : 2001 Jun

PMID : 11389120






4 Functional Relationships(s)
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1 We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
2 We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
3 Incubation of alveolar macrophages with different concentrations of azithromycin or clarithromycin modified IL-8 production: it increased at a drug concentration of 4 mg/L and decreased at concentration of 400 mg/L. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
4 Our findings suggest that azithromycin and clarithromycin may alter IL-8 production, thus enhancing the clinical effectiveness of these antibiotics. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens