Title : Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.

Pub. Date : 2001 May 15

PMID : 11358837






2 Functional Relationships(s)
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Protein Name
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1 We show here that hypoxia and cobalt treatment modulate the capacity of a HIF-1alpha fragment comprising residues 531-652 to coimmunoprecipitate with VHL. Cobalt hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Finally, evidence is provided to show that cobalt and hypoxia both induce a posttranslational modification (or loss of one) in HIF-1alpha that affects its binding to VHL. Cobalt hypoxia inducible factor 1 subunit alpha Homo sapiens