Title : Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

Pub. Date : 2001 Jun

PMID : 11356949






2 Functional Relationships(s)
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1 We examined a series of beta(2)-adrenoceptor (beta(2)AR) agonists (weak partial agonists to full agonists) for their efficacy at promoting two different steps of the G-protein activation/deactivation cycle: stabilizing the ternary complex (high-affinity, GTP-sensitive agonist binding), and steady-state GTPase activity. Guanosine Triphosphate adrenoceptor beta 2 Homo sapiens
2 We examined a series of beta(2)-adrenoceptor (beta(2)AR) agonists (weak partial agonists to full agonists) for their efficacy at promoting two different steps of the G-protein activation/deactivation cycle: stabilizing the ternary complex (high-affinity, GTP-sensitive agonist binding), and steady-state GTPase activity. Guanosine Triphosphate adrenoceptor beta 2 Homo sapiens