Title : Antiproliferative signaling of luteinizing hormone-releasing hormone in human endometrial and ovarian cancer cells through G protein alpha(I)-mediated activation of phosphotyrosine phosphatase.

Pub. Date : 2001 Jun

PMID : 11356684






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As shown by quantitative Western blotting, EGF-induced tyrosine autophosphorylation of EGF receptors was reduced 45-63% after LHRH (100 nM) treatment (P < 0.001). Tyrosine gonadotropin releasing hormone 1 Homo sapiens
2 The tumor LHRH receptor activates a PTP counteracting EGF-induced tyrosine autophosphorylation of EGF receptor, resulting in down-regulation of mitogenic signal transduction and cell proliferation. Tyrosine gonadotropin releasing hormone 1 Homo sapiens