Pub. Date : 2001 May 18
PMID : 11355955
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MDR1 causes resistance to the antitumour drug miltefosine. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | We investigated the sensitivity of MDR1 -expressing cells to treatment with miltefosine. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | We show that cells overexpressing MDR1 (NCI/ADR-RES, KB-8-5, KB-C1, CCRF/VCR1000, CCRF/ADR5000) were less sensitive to miltefosine treatment when compared to the sensitive parental cell lines. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | HeLa cells transfected with MDR1 exhibited resistance to the compound, indicating that expression of this gene is sufficient to reduce the sensitivity to miltefosine. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The resistance of MDR1-expressing cells to miltefosine was less pronounced than that to adriamycin or vinblastine. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | As shown by a fluorescence quenching assay using MIANS-labelled P-glycoprotein (PGP), miltefosine bound to PGP with a K(d)of approximately 7 microM and inhibited PGP-ATPase activity with an IC(50)of approximately 35 microM. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | As shown by a fluorescence quenching assay using MIANS-labelled P-glycoprotein (PGP), miltefosine bound to PGP with a K(d)of approximately 7 microM and inhibited PGP-ATPase activity with an IC(50)of approximately 35 microM. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | As shown by a fluorescence quenching assay using MIANS-labelled P-glycoprotein (PGP), miltefosine bound to PGP with a K(d)of approximately 7 microM and inhibited PGP-ATPase activity with an IC(50)of approximately 35 microM. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | As shown by a fluorescence quenching assay using MIANS-labelled P-glycoprotein (PGP), miltefosine bound to PGP with a K(d)of approximately 7 microM and inhibited PGP-ATPase activity with an IC(50)of approximately 35 microM. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 10 | These data indicate that expression of MDR1 may reduce the response to miltefosine in patients and that this compound interacts with PGP in a manner different from a number of other substrates. | miltefosine | ATP binding cassette subfamily B member 1 | Homo sapiens |