Pub. Date : 2001 Mar
PMID : 11354249
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide has been found to be a second messenger, which activates the c-jun N-terminal kinase (JNK) that is required for apoptotic cell death. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Ceramide has been found to be a second messenger, which activates the c-jun N-terminal kinase (JNK) that is required for apoptotic cell death. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Inhibition of ceramide production by desipramine (25-50 microM) reduced UV-induced JNK activation in both 293 and Jurkat cells; and protects 293 cells from UV-induced apoptosis. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | These results suggest that UV-induced JNK activation and apoptosis can be mediated through a ceramide dependent or an independent pathway. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |