Title : Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism.

Pub. Date : 2001 May 15

PMID : 11352889






1 Functional Relationships(s)
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1 In cultured cardiomyocytes treated with a mitochondrial inhibitor, HIF-1alpha mRNA and ET-1 mRNA were markedly increased with activated glycolysis, and antisense oligonucleotide for HIF-1alpha largely inhibited the increased gene expression of ET-1. Oligonucleotides hypoxia inducible factor 1 subunit alpha Rattus norvegicus