Pub. Date : 2001 Jan 12
PMID : 11341946
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of hyperoxia and iron on iron regulatory protein-1 activity and the ferritin synthesis in mouse peritoneal macrophages. | Iron | aconitase 1 | Mus musculus |
| 2 | In this paper, we have investigated the effect of hyperoxia and iron on the binding activity of IRP-1 and the ferritin synthesis in mouse peritoneal macrophages. | Iron | aconitase 1 | Mus musculus |
| 3 | Iron diminished the IRP-1-binding activity and the enhanced synthesis of ferritin. | Iron | aconitase 1 | Mus musculus |
| 4 | Consistently, hypoxia-induced loss of binding activity of IRP-1 and the enhanced synthesis of ferritin were blocked in the presence of an iron chelator deferoxamine. | Iron | aconitase 1 | Mus musculus |
| 5 | These alterations of the binding activity of IRP-1 in response to oxygen and iron were not reproduced in the cell-free extract. | Iron | aconitase 1 | Mus musculus |
| 6 | The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions. | Iron | aconitase 1 | Mus musculus |
| 7 | The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions. | Iron | aconitase 1 | Mus musculus |