PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11341946-0	2001	Effects of hyperoxia and iron on iron regulatory protein-1 activity and the ferritin synthesis in mouse peritoneal macrophages.	Iron	25-29	aconitase 1	Mus musculus	33-58	
11341946-2	2001	In this paper, we have investigated the effect of hyperoxia and iron on the binding activity of IRP-1 and the ferritin synthesis in mouse peritoneal macrophages.	Iron	64-68	aconitase 1	Mus musculus	96-101	
11341946-4	2001	Iron diminished the IRP-1-binding activity and the enhanced synthesis of ferritin.	Iron	0-4	aconitase 1	Mus musculus	20-25	
11341946-6	2001	Consistently, hypoxia-induced loss of binding activity of IRP-1 and the enhanced synthesis of ferritin were blocked in the presence of an iron chelator deferoxamine.	Iron	138-142	aconitase 1	Mus musculus	58-63	
11341946-7	2001	These alterations of the binding activity of IRP-1 in response to oxygen and iron were not reproduced in the cell-free extract.	Iron	77-81	aconitase 1	Mus musculus	45-50	
11341946-8	2001	The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions.	Iron	52-56	aconitase 1	Mus musculus	98-103	
11341946-8	2001	The data suggest that in the macrophages oxygen and iron inversely act on the binding activity of IRP-1 and the ferritin synthesis, and that intracellular mechanism(s) to sense iron and/or oxygen is required for these actions.	Iron	177-181	aconitase 1	Mus musculus	98-103