Title : Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets.

Pub. Date : 2001 May

PMID : 11334442






2 Functional Relationships(s)
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1 Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets. Calcium CD38 molecule Homo sapiens
2 We tested whether human anti-CD38 antibodies possess signaling properties by measuring their ability to raise intracellular calcium ([Ca2+]i) using the fluo-3-acetoxymethyl ester method in a human-derived T-cell line (Jurkat T-cells, expressing high levels of surface CD38) and in dispersed human islet cells from normal donors. Calcium CD38 molecule Homo sapiens