Title : Inhibition of X-ray and doxorubicin-induced apoptosis by butyrolactone I, a CDK-specific inhibitor, in human tumor cells.

Pub. Date : 2000 Dec

PMID : 11329882






1 Functional Relationships(s)
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1 In this study, we found that butyrolactone I, a specific inhibitor of CDC2 family kinases, blocks the X-ray- or doxorubicin-induced apoptosis of DLD1 (p21+/+) human colorectal carcinoma cells in a dose-dependent manner. Doxorubicin cyclin dependent kinase 1 Homo sapiens