Title : Prostaglandin F2alpha upregulates interleukin-6 production in human gingival fibroblasts.

Pub. Date : 2001 Apr

PMID : 11327082






2 Functional Relationships(s)
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1 Since FP receptors are coupled to elevation of intracellular calcium and activation of protein kinase C (PKC), the mechanism of IL-6 production by PGF2alpha was investigated using TMB-8, an inhibitor of Ca2+ mobilization from intracellular stores, and calphostin C, an inhibitor of PKC. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate interleukin 6 Homo sapiens
2 TMB-8 significantly suppressed PGF2alpha-induced IL-6 production, whereas calphostin C showed a stimulatory effect on PGF2alpha-induced IL-6 production. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate interleukin 6 Homo sapiens