Pub. Date : 2001 Apr 30
PMID : 11325610
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of human umbilical vein endothelial cells (HUVECs) with 7-ketocholesterol resulted in an increased release of soluble vascular cell adhesion molecule-1 (VCAM-1) into culture medium. | 7-ketocholesterol | vascular cell adhesion molecule 1 | Homo sapiens |
| 2 | Treatment of human umbilical vein endothelial cells (HUVECs) with 7-ketocholesterol resulted in an increased release of soluble vascular cell adhesion molecule-1 (VCAM-1) into culture medium. | 7-ketocholesterol | vascular cell adhesion molecule 1 | Homo sapiens |
| 3 | Western blot analysis revealed that soluble VCAM-1, in the conditioned medium of both 7-ketocholesterol-stimulated and control cells, had a molecular size of 100 kDa. | 7-ketocholesterol | vascular cell adhesion molecule 1 | Homo sapiens |
| 4 | Stimulation of the TNF-alpha-treated HUVECs with 7-ketocholesterol further increased the levels of soluble VCAM-1 in the culture medium. | 7-ketocholesterol | vascular cell adhesion molecule 1 | Homo sapiens |
| 5 | Pretreatment of the cells with tissue inhibitor of membrane metalloproteinase-2 (TIMP-2) completely inhibited the release of VCAM-1 in response to 7-ketocholesterol but TIMP-1 had no effect. | 7-ketocholesterol | vascular cell adhesion molecule 1 | Homo sapiens |
| 6 | We conclude that 7-ketocholesterol releases VCAM-1 from the endothelium probably by a proteolytic process. | 7-ketocholesterol | vascular cell adhesion molecule 1 | Homo sapiens |