Pub. Date : 2001 May
PMID : 11313312
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined the role of DMT1 and the mucosal iron uptake defect in HFE-knockout mice. | Iron | homeostatic iron regulator | Mus musculus |
| 2 | RESULTS: Ferrous iron uptake at 3.5-450 micromol/L was greatly enhanced in HFE-knockouts compared with wild-type, the apparent V(max) for Fe2+ transport being doubled (P < 0.01). | Iron | homeostatic iron regulator | Mus musculus |
| 3 | Supplied as Fe3+, uptake was only enhanced in HFE-knockouts at < or =18 micromol/L, when the iron was almost completely converted to Fe2+ by mucosal ferrireductases. | Iron | homeostatic iron regulator | Mus musculus |
| 4 | CONCLUSIONS: Disruption of the HFE gene up-regulates functional DMT1 transporters and enhances uptake of ferrous iron by this mechanism; DMT1 also mediates increased uptake after reduction of ferric iron presented at physiological concentrations. | Iron | homeostatic iron regulator | Mus musculus |