| Protein Name | homeostatic iron regulator |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15216 |
| Gene Symbol | Hfe |
| UniProt | P70387 (HFE_MOUSE), Q5SZ87 (Q5SZ87_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
46
Total Number of Articles : 190 |
Description |
homeostatic iron regulator |
| Gene Summary |
Enables transferrin receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain; choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |