Title : Transient down-regulation of NMDA receptor subunit gene expression in the rat retina following NMDA-induced neurotoxicity is attenuated in the presence of the non-competitive NMDA receptor antagonist MK-801.

Pub. Date : 2001 May

PMID : 11311046






2 Functional Relationships(s)
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1 Following NMDA insult, the mRNA levels for NR1(com ), NR2A, NR2B and, to a lesser extent, the NR2C subunit were substantially reduced within 24 hr post-treatment (PT), and remained depressed for up to 48 hr. N-Methylaspartate glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus
2 Of the five genes assayed, NR2A and NR2B showed the greatest reduction in expression following NMDA treatment, suggesting that one or both of these subunit may signal events leading to neuronal cell death in the retina. N-Methylaspartate glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus