Title : Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for chromosome-associated Chk in chromosome dynamics.

Pub. Date : 2001 May

PMID : 11309195






4 Functional Relationships(s)
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Protein Name
Organism
1 Chk overexpression induced a decrease in autophosphorylation of Lyn and concomitant changes in levels of tyrosine phosphorylation of proteins associated with both fractions. Tyrosine megakaryocyte-associated tyrosine kinase Homo sapiens
2 These results indicate that Chk, Lyn and the tyrosine-phosphorylated proteins localize to mitotic chromosomes and spindles, suggesting that Chk-dependent tyrosine phosphorylation, presumably through Lyn, may be involved in chromosome dynamics. Tyrosine megakaryocyte-associated tyrosine kinase Homo sapiens
3 These results indicate that Chk, Lyn and the tyrosine-phosphorylated proteins localize to mitotic chromosomes and spindles, suggesting that Chk-dependent tyrosine phosphorylation, presumably through Lyn, may be involved in chromosome dynamics. Tyrosine megakaryocyte-associated tyrosine kinase Homo sapiens
4 These results indicate that Chk, Lyn and the tyrosine-phosphorylated proteins localize to mitotic chromosomes and spindles, suggesting that Chk-dependent tyrosine phosphorylation, presumably through Lyn, may be involved in chromosome dynamics. Tyrosine megakaryocyte-associated tyrosine kinase Homo sapiens