Protein Name | megakaryocyte-associated tyrosine kinase |
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Organism | Homo sapiens |
Gene ID | 4145 |
Gene Symbol | MATK |
UniProt | P42679 (MATK_HUMAN), F1T0G6 (F1T0G6_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
84
Total Number of Articles : 75 |
Description |
megakaryocyte-associated tyrosine kinase |
Gene Summary |
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
synonyms |
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Properties | |