Protein Name megakaryocyte-associated tyrosine kinase
Organism Homo sapiens
Gene ID 4145
Gene Symbol

MATK

UniProt P42679 (MATK_HUMAN), F1T0G6 (F1T0G6_HUMAN)
Relationships Total Number of functionally related compound(s) : 84
Total Number of Articles : 75
Description

megakaryocyte-associated tyrosine kinase

Gene Summary

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

synonyms
  • megakaryocyte-associated tyrosine-protein kinase
  • CSK homologous kinase
  • Csk-homologous kinase
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Properties