Title : PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice.

Pub. Date : 2001 Apr

PMID : 11306606






2 Functional Relationships(s)
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1 Despite gaining as much or more weight than their PPARalpha(+/+)apoE(-/-) littermates, PPARalpha(-/-)apoE(-/-) mice had lower fasting levels of glucose and insulin. Glucose peroxisome proliferator activated receptor alpha Mus musculus
2 PPARalpha-null animals had greater suppression of endogenous glucose production in hyperinsulinemic clamp experiments, reflecting less insulin resistance in the absence of PPARalpha. Glucose peroxisome proliferator activated receptor alpha Mus musculus