Title : Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.

Pub. Date : 2001 Jan 30

PMID : 11306074






1 Functional Relationships(s)
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1 Numerous physiological aldehydes besides glucose are substrates of aldose reductase, the first enzyme of the polyol pathway which has been implicated in the etiology of diabetic complications. Glucose aldo-keto reductase family 1 member B Homo sapiens