Title : Angiotensin-(1-7) downregulates the angiotensin II type 1 receptor in vascular smooth muscle cells.

Pub. Date : 2001 Apr

PMID : 11304516






2 Functional Relationships(s)
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1 The pretreatment of vascular smooth muscle cells with Ang-(1-7) followed by treatment with acidic glycine to remove surface-bound peptide resulted in a significant decrease in [(125)I]Ang II binding; however, reduced Ang II binding was observed only at micromolar concentrations of Ang-(1-7). Glycine angiotensinogen Rattus norvegicus
2 The pretreatment of vascular smooth muscle cells with Ang-(1-7) followed by treatment with acidic glycine to remove surface-bound peptide resulted in a significant decrease in [(125)I]Ang II binding; however, reduced Ang II binding was observed only at micromolar concentrations of Ang-(1-7). Glycine angiotensinogen Rattus norvegicus