Pub. Date : 2001 Apr 6
PMID : 11301060
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole. | Pramipexole | synuclein alpha | Homo sapiens |
| 2 | In the present study, we examined the effects of talipexole and pramipexole on the release of cytochrome c and alpha-synuclein, their aggregations, and activation of caspases. | Pramipexole | synuclein alpha | Homo sapiens |
| 3 | Talipexole and pramipexole at low concentration (0.1-1 mM) significantly inhibited the accumulation of cytochrome c or alpha-synuclein in the cytosolic fraction. | Pramipexole | synuclein alpha | Homo sapiens |
| 4 | These results suggest that talipexole and pramipexole may have protective effects against the neurodegeneration, which is induced by intracellular accumulation of cytochrome c and alpha-synuclein. | Pramipexole | synuclein alpha | Homo sapiens |