Title : Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions.

Pub. Date : 2001 Apr 3

PMID : 11300774






1 Functional Relationships(s)
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1 We conclude that the residues corresponding to eNTPDase-3 glutamate 182 in ACR3 and serine 224 in ACR4 are essential for the enzymatic activity of eNTPDases in general, and that arginine 67, arginine 146, asparagine 191, and glutamine 226 are important for determining substrate specificity for human ecto-nucleoside triphosphate diphosphohydrolase 3. Glutamine ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens