PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11300774-9 2001 We conclude that the residues corresponding to eNTPDase-3 glutamate 182 in ACR3 and serine 224 in ACR4 are essential for the enzymatic activity of eNTPDases in general, and that arginine 67, arginine 146, asparagine 191, and glutamine 226 are important for determining substrate specificity for human ecto-nucleoside triphosphate diphosphohydrolase 3. Glutamine 225-234 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 47-57