Title : A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes.

Pub. Date : 2001 May

PMID : 11294760






2 Functional Relationships(s)
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1 Pretreatment with an antisense oligodeoxyribonucleotide of Mn-SOD markedly attenuated the cytoprotective effect of ET-1 on the Dox-induced cytotoxicity. Doxorubicin superoxide dismutase 2 Rattus norvegicus
2 These results suggest that ET-1 prevents the early phase of Dox-induced cytotoxicity via the upregulation of the antioxidant Mn-SOD through ET(A) receptors in cultured cardiomyocytes. Doxorubicin superoxide dismutase 2 Rattus norvegicus