Title : Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity.

Pub. Date : 2001 Mar 15

PMID : 11289134






3 Functional Relationships(s)
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1 The IC50 value for DOX was 7-fold lower when combined with a low dose (100 nM) FP in pRb-deficient SaOs-2 cells than in the absence of FP. Doxorubicin RB transcriptional corepressor 1 Homo sapiens
2 Consistent with this, FP enhanced DOX-induced activation of caspase-3, which correlates with apoptosis, in pRb-deficient cells but not in pRb-restored cells. Doxorubicin RB transcriptional corepressor 1 Homo sapiens
3 We conclude that pRb plays a key role in determining whether FP selectively sensitizes DOX-induced cell killing in human sarcoma cells. Doxorubicin RB transcriptional corepressor 1 Homo sapiens