Pub. Date : 2001 May
PMID : 11282258
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, mice lacking the high affinity nAChR containing the beta2 subunit showed decreased place preference to 5 mg/kg cocaine, although higher doses of cocaine could condition a place preference in these knock out animals. | Cocaine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | In addition, mice lacking the high affinity nAChR containing the beta2 subunit showed decreased place preference to 5 mg/kg cocaine, although higher doses of cocaine could condition a place preference in these knock out animals. | Cocaine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | Induction of chronic fos-related antigens by cocaine was also reduced in mutant mice as compared to their wild type siblings, implying that downstream actions of cocaine were also affected by inactivation of the high affinity nAChR. | Cocaine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | These data indicate that activation of the high affinity nAChR may contribute to cocaine reinforcement. | Cocaine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |