Pub. Date : 2001 Mar 1
PMID : 11280726
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. | geldanamycin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. | geldanamycin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Present studies demonstrate that treatment with ansamycin antibiotic geldanamycin (GA), or its less toxic analogue 17-allylamino-17-demethoxygeldanamycin (17-AAG), induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells. | geldanamycin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Present studies demonstrate that treatment with ansamycin antibiotic geldanamycin (GA), or its less toxic analogue 17-allylamino-17-demethoxygeldanamycin (17-AAG), induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells. | geldanamycin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | GA or 17-AAG down-regulated intracellular Bcr-Abl and c-Raf protein levels, as well as reduced Akt kinase activity. | geldanamycin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 6 | These data establish the in vitro activity of GA and 17-AAG against Bcr-Abl-positive leukemic cells and support the in vivo investigation of 17-AAG against Bcr-Abl-positive leukemias. | geldanamycin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |