Pub. Date : 2001 Jun 15
PMID : 11278991
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. | Threonine | cyclin dependent kinase 2 | Homo sapiens |
| 2 | Here, we identified that threonine 199 (Thr(199)) of NPM/B23 is the major phosphorylation target site of CDK2-cyclin E in vitro, and the same site is phosphorylated in vivo. | Threonine | cyclin dependent kinase 2 | Homo sapiens |
| 3 | Here, we identified that threonine 199 (Thr(199)) of NPM/B23 is the major phosphorylation target site of CDK2-cyclin E in vitro, and the same site is phosphorylated in vivo. | Threonine | cyclin dependent kinase 2 | Homo sapiens |
| 4 | These observations provide direct evidence that the CDK2-cyclin E-mediated phosphorylation on Thr(199) determines association and dissociation of NPM/B23 to the centrosomes, which is a critical control for the centrosome to initiate duplication. | Threonine | cyclin dependent kinase 2 | Homo sapiens |