Title : Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells.

Pub. Date : 2001 Mar 23

PMID : 11278000






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Binding of drugs (4-demethoxy-daunorubicin and 3"-(3-methoxymorpholino)doxorubicin) which accumulate in resistant cells immobilizes MRP1 in a conformational state that is insensitive to ATP binding whereas drugs rejected outside the resistant cells (daunorubicin, doxorubicin) favor a conformational change which may be a required step in the transport process. Idarubicin ATP binding cassette subfamily C member 1 Homo sapiens