Pub. Date : 2001 Jun
PMID : 11275291
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine-induced behavioral sensitization is associated with extracellular dopamine release and expression of c-Fos in the striatum and nucleus accumbens of the rat. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | This study was carried out to investigate the neural mechanisms underlying nicotine-induced behavioral sensitization using in vivo microdialysis and Fos-like immunohistochemistry (FLI). | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | Furthermore, in parallel with the behavioral and biochemical data, systemic challenge with nicotine produced marked Fos-like immunohistochemistry in the nucleus accumbens and the striatum in the nicotine-pretreated rats. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | Furthermore, in parallel with the behavioral and biochemical data, systemic challenge with nicotine produced marked Fos-like immunohistochemistry in the nucleus accumbens and the striatum in the nicotine-pretreated rats. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | Taken together, this study demonstrates that behavioral sensitization is clearly associated with an increase in DA release and activation of Fos-like immunoreactive cells in the striatum and the nucleus accumbens produced by repeated nicotine treatment. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |