Title : Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway.

Pub. Date : 2001 Apr 1

PMID : 11264150






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Exogenously added GlcCer and the homologous Glc-containing globotriaosylceramide (Gb3Cer), but not galactosylceramide, dose-dependently prolonged clotting times of normal plasma in the presence, but not absence, of APC:protein S, which suggests that GlcCer or Gb3Cer can enhance protein C pathway anticoagulant activity. Glucose alpha 1,4-galactosyltransferase (P blood group) Homo sapiens