Title : Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes.

Pub. Date : 2001 Apr

PMID : 11259624






1 Functional Relationships(s)
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1 Salicylate alone was not toxic, and the enhanced toxicity by AA in the presence of salicylate was prevented by diallyl sulfide, a CYP2E1 inhibitor, and by the antioxidant (+/-)6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid. allyl sulfide cytochrome P450 family 2 subfamily E member 1 Homo sapiens