Pub. Date : 2001 Apr
PMID : 11259331
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have identified CYP2C19 and CYP3A4 as the principal cytochrome P450s involved in the metabolism of flunitrazepam to its major metabolites desmethylflunitrazepam and 3-hydroxyflunitrazepam. | Flunitrazepam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | We estimate that the relative contributions of CYP2C19 and CYP3A4 to the formation of desmethylflunitrazepam in vivo are 63 and 37%, respectively, at therapeutic flunitrazepam concentrations (0.03 microM). | Flunitrazepam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |