Title : Mechanism of CGRP-induced relaxation in rat intramural coronary arteries.

Pub. Date : 2001 Mar

PMID : 11250874






3 Functional Relationships(s)
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1 In 300 nM U46619-precontracted arteries, pretreatment with either 100 nM charybdotoxin or 100 nM iberiotoxin or 10 nM felodipine significantly (P<0.05) attenuated the CGRP-induced reduction in both [Ca(2+)](i) and tension. Charybdotoxin calcitonin-related polypeptide alpha Rattus norvegicus
2 In resting coronary arteries, only pretreatment with the combination of 1 microM glibenclamide and 100 nM charybdotoxin attenuated the CGRP-induced decrease in the [Ca(2+)](i) and tension, suggesting a different mechanism of action for CGRP in resting coronary arteries. Charybdotoxin calcitonin-related polypeptide alpha Rattus norvegicus
3 In resting coronary arteries, only pretreatment with the combination of 1 microM glibenclamide and 100 nM charybdotoxin attenuated the CGRP-induced decrease in the [Ca(2+)](i) and tension, suggesting a different mechanism of action for CGRP in resting coronary arteries. Charybdotoxin calcitonin-related polypeptide alpha Rattus norvegicus