Title : Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells.

Pub. Date : 2001 Apr

PMID : 11249854






2 Functional Relationships(s)
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1 Furthermore, pretreatment of cells with exogenous ET-1 obviously prevented cytochalasin D-elicited activation of MMP-2, an effect that was completely abolished by ET(A) receptor antagonist, FR139317. Cytochalasin D matrix metallopeptidase 2 Rattus norvegicus
2 The addition of recombinant TIMP-2 into the culture abrogated dose-dependently the cytochalasin D-elicited activation of MMP-2. Cytochalasin D matrix metallopeptidase 2 Rattus norvegicus