Title : Preliminary report on the effect of xenoperfusion with human blood on cyclosporin A metabolism and cytochrome-P-4503A4-mRNA expression in a pig liver perfusion model.

Pub. Date : 2001 Feb

PMID : 11239516






1 Functional Relationships(s)
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1 OBJECTIVES: Little is known about the effect of ischemia/reperfusion with xenogenic blood on function and gene expression of CYP3A4, the enzyme largely responsible for the metabolism of the immunosuppressants Cyclosporin A (CsA) and Tacrolimus. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens