Title : Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step.

Pub. Date : 2001 Mar 15

PMID : 11238994






2 Functional Relationships(s)
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1 To minimise the mutagenic potential of this oxidised purine, human cells have a specific 8-oxoG DNA glycosylase/AP lyase (hOGG1) that initiates the base excision repair (BER) of 8-oxoG. purine 8-oxoguanine DNA glycosylase Homo sapiens
2 To minimise the mutagenic potential of this oxidised purine, human cells have a specific 8-oxoG DNA glycosylase/AP lyase (hOGG1) that initiates the base excision repair (BER) of 8-oxoG. purine 8-oxoguanine DNA glycosylase Homo sapiens