Pub. Date : 2001 Mar
PMID : 11238722
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 2 | Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 3 | Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 4 | Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA). | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 5 | Mutagenesis of either the cAMP responsive element (CRE) or the activator protein-1 element (AP1) within the TH gene proximal promoter leads to a dramatic inhibition of the TPA response. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 6 | The TH CRE and TH AP1 sites are also independently responsive to TPA in minimal promoter constructs. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 7 | In CREB-deficient cells, the response of the full TH gene proximal promoter or the independent response of the TH CRE by itself to TPA is inhibited. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 8 | The TPA-inducibility of TH mRNA is also blocked in CREB-deficient cells. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 9 | Expression of the PKA inhibitor protein, PKI, also inhibits the independent response of the TH CRE to TPA. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 10 | Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 11 | Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |
| 12 | Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites. | Tetradecanoylphorbol Acetate | tyrosine hydroxylase | Rattus norvegicus |