Pub. Date : 2001 Feb 6
PMID : 11231159
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both generation of Ran-GTP by the guanine nucleotide exchange factor RCC1 and GTP hydrolysis by Ran are required for NE assembly, although the roles of the GDP- and GTP-bound forms of Ran in the recruitment of precursor vesicles and their fusion have been unclear. | Guanosine Triphosphate | RAN, member RAS oncogene family | Homo sapiens |
| 2 | Both generation of Ran-GTP by the guanine nucleotide exchange factor RCC1 and GTP hydrolysis by Ran are required for NE assembly, although the roles of the GDP- and GTP-bound forms of Ran in the recruitment of precursor vesicles and their fusion have been unclear. | Guanosine Triphosphate | RAN, member RAS oncogene family | Homo sapiens |
| 3 | Both generation of Ran-GTP by the guanine nucleotide exchange factor RCC1 and GTP hydrolysis by Ran are required for NE assembly, although the roles of the GDP- and GTP-bound forms of Ran in the recruitment of precursor vesicles and their fusion have been unclear. | Guanosine Triphosphate | RAN, member RAS oncogene family | Homo sapiens |
| 4 | However, addition of antibodies to RCC1 and RanGAP1 shows that Ran-GDP must be converted to Ran-GTP by RCC1 before precursor vesicles are recruited, whereas GTP hydrolysis by Ran stimulated by RanGAP1 promotes vesicle recruitment and is necessary for vesicle fusion to form an intact envelope. | Guanosine Triphosphate | RAN, member RAS oncogene family | Homo sapiens |
| 5 | However, addition of antibodies to RCC1 and RanGAP1 shows that Ran-GDP must be converted to Ran-GTP by RCC1 before precursor vesicles are recruited, whereas GTP hydrolysis by Ran stimulated by RanGAP1 promotes vesicle recruitment and is necessary for vesicle fusion to form an intact envelope. | Guanosine Triphosphate | RAN, member RAS oncogene family | Homo sapiens |
| 6 | Thus, the GTP-GDP cycle of Ran controls both the recruitment of vesicles and their fusion to form NEs. | Guanosine Triphosphate | RAN, member RAS oncogene family | Homo sapiens |