PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11231159-3	2001	Both generation of Ran-GTP by the guanine nucleotide exchange factor RCC1 and GTP hydrolysis by Ran are required for NE assembly, although the roles of the GDP- and GTP-bound forms of Ran in the recruitment of precursor vesicles and their fusion have been unclear.	Guanosine Triphosphate	23-26	RAN, member RAS oncogene family	Homo sapiens	19-22	
11231159-3	2001	Both generation of Ran-GTP by the guanine nucleotide exchange factor RCC1 and GTP hydrolysis by Ran are required for NE assembly, although the roles of the GDP- and GTP-bound forms of Ran in the recruitment of precursor vesicles and their fusion have been unclear.	Guanosine Triphosphate	78-81	RAN, member RAS oncogene family	Homo sapiens	96-99	
11231159-3	2001	Both generation of Ran-GTP by the guanine nucleotide exchange factor RCC1 and GTP hydrolysis by Ran are required for NE assembly, although the roles of the GDP- and GTP-bound forms of Ran in the recruitment of precursor vesicles and their fusion have been unclear.	Guanosine Triphosphate	78-81	RAN, member RAS oncogene family	Homo sapiens	96-99	
11231159-6	2001	However, addition of antibodies to RCC1 and RanGAP1 shows that Ran-GDP must be converted to Ran-GTP by RCC1 before precursor vesicles are recruited, whereas GTP hydrolysis by Ran stimulated by RanGAP1 promotes vesicle recruitment and is necessary for vesicle fusion to form an intact envelope.	Guanosine Triphosphate	96-99	RAN, member RAS oncogene family	Homo sapiens	63-66	
11231159-6	2001	However, addition of antibodies to RCC1 and RanGAP1 shows that Ran-GDP must be converted to Ran-GTP by RCC1 before precursor vesicles are recruited, whereas GTP hydrolysis by Ran stimulated by RanGAP1 promotes vesicle recruitment and is necessary for vesicle fusion to form an intact envelope.	Guanosine Triphosphate	96-99	RAN, member RAS oncogene family	Homo sapiens	63-66	
11231159-7	2001	Thus, the GTP-GDP cycle of Ran controls both the recruitment of vesicles and their fusion to form NEs.	Guanosine Triphosphate	10-13	RAN, member RAS oncogene family	Homo sapiens	27-30