Title : Phorbol ester responsiveness of the glutathione S-transferase P1 gene promoter involves an inducible c-jun binding in human K562 leukemia cells.

Pub. Date : 2001 Mar

PMID : 11226521






3 Functional Relationships(s)
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1 Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription. Tetradecanoylphorbol Acetate glutathione S-transferase pi 1 Homo sapiens
2 Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription. Tetradecanoylphorbol Acetate glutathione S-transferase pi 1 Homo sapiens
3 These results show for the first time that the phorbol ester TPA is involved in the molecular mechanism(s) mediating the activation of the GSTP1 promoter in a human leukemia model. Tetradecanoylphorbol Acetate glutathione S-transferase pi 1 Homo sapiens