Pub. Date : 2001 Feb 15
PMID : 11226373
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. | Thiabendazole | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | Carbaryl and thiabendazole, two widely used pesticides, have been shown to induce cytochrome P450 1A1 (CYP1A1) expression, but neither compound is capable of displacing [3H] 2,3,7,8-tetrachlorodibenzo-P-dioxin from its aryl hydrocarbon receptor binding site. | Thiabendazole | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Carbaryl and thiabendazole, two widely used pesticides, have been shown to induce cytochrome P450 1A1 (CYP1A1) expression, but neither compound is capable of displacing [3H] 2,3,7,8-tetrachlorodibenzo-P-dioxin from its aryl hydrocarbon receptor binding site. | Thiabendazole | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Carbaryl and thiabendazole were found to activate CYP1A1 at the level of transcription, as demonstrated by the dose-dependent increase in reporter CAT and CYP1A1 mRNAs. | Thiabendazole | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | Carbaryl and thiabendazole were found to activate CYP1A1 at the level of transcription, as demonstrated by the dose-dependent increase in reporter CAT and CYP1A1 mRNAs. | Thiabendazole | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | Both compounds provoked a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. | Thiabendazole | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |