Title : Effect of cyclosporin-A on the blood--retinal barrier permeability in streptozotocin-induced diabetes.

Pub. Date : 2000

PMID : 11200365






3 Functional Relationships(s)
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1 AIMS: The aim of this work was to examine whether the administration of cyclosporin-A (Cs-A) to STZ-induced diabetic rats inhibits the synthesis of IL-1beta and the expression of the inducible proteins, iNOS and cyclo-oxygenase-2 (COX-2) in retinal cells, and whether the activity of these proteins contribute to BRB breakdown. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
2 AIMS: The aim of this work was to examine whether the administration of cyclosporin-A (Cs-A) to STZ-induced diabetic rats inhibits the synthesis of IL-1beta and the expression of the inducible proteins, iNOS and cyclo-oxygenase-2 (COX-2) in retinal cells, and whether the activity of these proteins contribute to BRB breakdown. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
3 The treatment of diabetic rats with Cs-A also significantly inhibited the expression of the inducible proteins, iNOS and COX-2. Cyclosporine nitric oxide synthase 2 Rattus norvegicus