Pub. Date : 2001 Mar
PMID : 11181490
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compounds known to activate the pregnane X receptor (PXR) such as rifampicin, or the constitutively activated receptor (CAR) such as phenobarbital, induced CYP2C8, CYP2C9, and to a lesser extent CYP2C19 mRNAs and proteins. | Phenobarbital | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 2 | The concentration dependence of CYP2C8 and CYP2C9 mRNAs in response to rifampicin and phenobarbital paralleled that of CYP3A4 and CYP2B6, the maximum accumulation being reached with 10 microM rifampicin and 100 microM phenobarbital. | Phenobarbital | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 3 | The concentration dependence of CYP2C8 and CYP2C9 mRNAs in response to rifampicin and phenobarbital paralleled that of CYP3A4 and CYP2B6, the maximum accumulation being reached with 10 microM rifampicin and 100 microM phenobarbital. | Phenobarbital | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 4 | Furthermore, dexamethasone, which has been recently shown to up-regulate PXR and CAR expression through the glucocorticoid receptor, potentiated CYP2C8 and CYP2C9 mRNA induction in response to rifampicin and phenobarbital. | Phenobarbital | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |